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If you are wondering why you haven't noticed a change yet, consider these variables: 1

Poehlman ET, Arciero PJ, Melby CL, et al

In addition, it has been suggested that GDF11 and GDF15 inhibit erythroid maturation through activation of activin receptors IIA (ActRIIA) and IIB (ActRIIB) (Suragani et al., 2014b)